InVivoMAb anti-rat CTLA-4 (CD152)
货号 #BE0424
克隆号:
WKH203
反应种属:
Rat
￥1,792 - ￥46,736
产品详情
The WKH203 monoclonal antibody reacts with rat CTLA-4 (cytotoxic T-lymphocyte- antigen 4) (CTLA-4), also known as CD152. CTLA-4 is an inhibitory receptor acting as a key negative regulator of T-cell immune responses. CTLA-4 protein is expressed by activated T cells and by suppressor T regulatory cells. Rat CTLA-4 is a 223 amino acid long single-pass type I membrane protein (encoded by gene Ctla4) and has a predicted molecular weight of 24.9 kDa. CTLA-4 has structural similarities to the T-cell co-stimulatory protein CD28, and both of these molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). CTLA-4’s affinity for its natural B7 family ligands CD80 and CD86 is significantly higher than the affinity of their cognate stimulatory co-receptor CD28. CTLA-4 plays key roles in induction and/or maintenance of immunological tolerance, thymocyte development, and regulation of protective immunity. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. In the last two decades, extensive research on CTLA-4 has led to the clinical approval of therapeutic antibodies for treatment of advanced metastatic melanoma and liver cancer. The binding of the CTLA-4 antibody to the CTLA-4 protein disrupts the key signaling mechanisms linked to the suppression of T cell activity, triggering T cells readily and enhancing the immune system’s capacity to identify and eliminate cancer.参数
| 同种型 | Mouse IgG1, κ |
|---|---|
| 推荐的同型对照 | InVivoMAb mouse IgG1 isotype control, unknown specificity |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Purified rat CTLA-4hIg fusion protein |
| Reported Applications | in vitro CTLA-4 neutralization Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein G |
| 分子量 | 150 kDa |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Isotype Control(s)
InVivoMAb mouse IgG1 isotype control, unknown specificity
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
