InVivoSIM anti-human ActRIIA (ACVR2A), ActRIIB (ACVR2B) (Bimagrumab Biosimilar)
货号 #SIM0086
克隆号:
Bimagrumab
反应种属:
Human
￥5,824 - ￥78,848
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Bimagrumab, making it ideal for research use. Bimagrumab is a fully human IgG1 monoclonal antibody that targets the activin type II receptors ActRIIA (ACVR2A) and ActRIIB (ACVR2B), which are members of the TGF-β receptor superfamily. ActRIIA and ActRIIB are broadly expressed on skeletal muscle cells and other tissues, where they mediate signaling of myostatin, activins, and related ligands. These signaling pathways normally limit muscle growth and contribute to muscle wasting in a variety of pathological settings. By binding to and blocking ActRIIA/ActRIIB, Bimagrumab inhibits ligand–receptor interactions, thereby releasing the inhibitory brake on muscle growth and promoting hypertrophy. In clinical studies, Bimagrumab has been shown to increase lean body mass and muscle strength in patients with sarcopenia, cancer cachexia, and neuromuscular disorders, although its therapeutic development has focused primarily on muscle wasting diseases and metabolic disorders such as obesity and type 2 diabetes. This Bimagrumab biosimilar is well suited for investigating TGF-β family receptor signaling, muscle biology, sarcopenia, cachexia, obesity, and therapeutic approaches aimed at enhancing muscle mass and metabolic health.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human ActRIIA and ActRIIB |
| Reported Applications | In vivo functional assays in vitro functional assays Flow cytometry ELISA |
| 形式 | pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
