InVivoSIM anti-human CD27 (Varlilumab Biosimilar)
货号 #SIM0087
克隆号:
Varlilumab
反应种属:
Human
￥2,527 - ￥87,620
产品详情
This non‑therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Varlilumab, making it ideal for research use. Varlilumab is a human IgG1 monoclonal antibody that specifically targets CD27, a member of the tumor necrosis factor receptor (TNFR) superfamily. CD27 is a co-stimulatory immune receptor that is constitutively expressed on naive and memory T cells, and can also be found on regulatory T cells (Tregs), NK cells, and some B cells. Engagement of CD27 by its ligand, CD70, promotes T cell activation, survival, and effector function, playing a key role in regulating immune responses and maintaining long-term immunity. Varlilumab is an agonist antibody that mimics CD70 binding, delivering potent co-stimulatory signals to T cells while also depleting CD27⁺ regulatory T cells via Fc-mediated effector mechanisms. Varlilumab has shown therapeutic potential in enhancing anti-tumor immunity in cancer models and has been investigated in combination with immune checkpoint inhibitors such as anti-PD-1. This Varlilumab biosimilar is ideal for studying CD27 signaling, T cell costimulation, Treg modulation, and combination immunotherapy mechanisms in both in vitro and in vivo settings.参数
| 同种型 | Human IgG4, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG4 (S228P) isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CD27 |
| Reported Applications | In vivo functional assays in vitro functional assays Flow cytometry Western blot ELISA |
| 形式 | pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG4 (S228P) isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
