InVivoSIM anti-human CD30 (Brentuximab Biosimilar)
货号 #SIM0073
克隆号:
Brentuximab
￥2,527 - ￥87,620
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Brentuximab, making it ideal for research use. Brentuximab is a humanized IgG1 monoclonal antibody that targets CD30, also known as TNF Receptor Superfamily Member 8 (TNFRSF8), D1S166E, or Ki-1. The CD30 receptor is a 120 kDa glycoprotein antigen that is highly expressed in CD8+ and CD4+ lymphocytes. The CD30 receptor’s ligand is a membrane-bound cytokine, CD30L, that is expressed on activated granulocytes and lymphocytes. The binding of the CD30 receptor to its ligand CD30L activates the receptor activity that leads to the recruitment of TNF-related factors (TRAF1, TRAF2, and TRAF3) and signaling complex formation, thereby stimulating the anti-apoptotic and pro-survival pathways (NFkB and MAPK) in tumors. Besides activated lymphocytes, the CD30 receptor is expressed in eosinophils, B cells, NK cells, dendritic cells (DC), and T regulatory cells (Treg), and its lack in peripheral blood cells makes it an attractive therapeutic target. Brentuximab is the antibody component of the brentuximab vedotin (BV) antibody–drug conjugate (ADC) that is reported to deliver the microtubule-disrupting drug monomethyl auristatin E (MMAE) to CD30+ cancer cells in studies involving Hodgkin lymphoma (HL), systemic anaplastic large cell lymphoma (sALCL), cutaneous T-cell lymphomas, primary cutaneous anaplastic large cell lymphoma (pcALCL), peripheral T-cell lymphoma (PTCL), and mycosis fungoides (MF).参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CD30 |
| Reported Applications | Functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
