InVivoSIM anti-human CD38 (Isatuximab Biosimilar)
货号 #SIM0092
克隆号:
Isatuximab
￥2,527 - ￥87,620
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Isatuximab, making it ideal for research use. Isatuximab is a chimeric IgG1 monoclonal antibody that specifically targets human CD38, a multifunctional transmembrane glycoprotein highly expressed on malignant plasma cells and other hematologic tumor cells, but also found at lower levels on subsets of immune cells such as NK cells, regulatory T cells, B cells, and some myeloid cells. CD38 has both receptor and ectoenzyme functions, contributing to cell adhesion, signal transduction, calcium mobilization, and NAD+ metabolism. By binding CD38, Isatuximab induces tumor cell death through multiple mechanisms including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and direct pro-apoptotic signaling. In the clinic, Isatuximab is approved for the treatment of multiple myeloma, where it has shown efficacy in reducing tumor burden and extending survival when combined with standard-of-care therapies. This Isatuximab biosimilar is well suited for studying CD38 signaling, plasma cell biology, tumor immunology, immune regulation, and therapeutic strategies targeting multiple myeloma and other CD38-positive malignancies.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CD38 |
| Reported Applications | in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
