InVivoSIM anti-human CD40 (Sotigalimab Biosimilar)
货号 #SIM0072
克隆号:
Sotigalimab
￥2,527 - ￥87,620
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Sotigalimab, making it ideal for research use. Sotigalimab is a humanized IgG1 monoclonal antibody that targets CD40, also known as tumor necrosis factor receptor superfamily member 5 (TNFRSF5), P50, and CDW40. CD40 is a pivotal co-stimulatory receptor that is expressed by both non-immune cells (e.g., epithelial malignancies) as well as immune cells, including antigen-presenting cells such as dendritic cells, macrophages, and B lymphocytes. CD40’s interaction with its ligand CD40L (CD154) is essential to the activation of T cells (including CD8+ T cells), the maturation of B cells, and various immune system-related pathophysiological conditions. In cancers, the CD40-CD40L interaction can have different outcomes depending on the level of engagement, potentially promoting cell survival at low levels and inducing cell death at high levels. Consistent with CD40 engagement, experimental studies involving advanced solid tumors and the use of high-affinity CD40-agonistic antibody Sotigalimab have demonstrated this antibody to produce dose-dependent increases in APCs and T-cell activation. The sotigalimab biosimilar antibody is a valuable tool to explore and harness the power of CD40 signaling, immune cell activation, and anti-cancer immuno-therapeutics development.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CD40 |
| Reported Applications | Functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
-
Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
