InVivoSIM anti-human CEACAM5 (Labetuzumab Biosimilar)
货号 #SIM0039
克隆号:
Labetuzumab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody, Labetuzumab, making it ideal for research use. This Labetuzumab biosimilar is a humanized anti-carcinoembryonic antigen antibody, and it reacts with carcinoembryonic antigen-related cell adhesion molecule 5 (i.e., CEACAM5), which is also called CEA or CD66e. During fetal or early embryonic stages, CEACAM5 is expressed in the digestive system, and it is found over-expressed in cancerous tissues. CEACAM5 acts as a cell adhesion molecule (CAM), and it inhibits anoikis, a type of apoptosis that is induced upon cell detachment from the ECM. Through this mechanism, CEACAM5 facilitates tumorigenesis and metastasis. CEACAM5 expression is often found upregulated in a variety of human epithelial malignancies, such as breast cancer, colon cancer, lung cancer, neuro-endocrine prostate cancer (NEPC), and pancreatic cancers. In cancer immunotherapy research, CEACAM5-targeted vaccines, bispecific T cell engagers (BiTEs), CAR T cell therapies, and antibody-drug conjugates are routinely tested in various experimental models. In vitro and in vivo studies involving the use of the humanized anti-carcinoembryonic antigen antibody Labetuzumab have shown the antibody to inhibit the cell proliferation and growth of CEACAM5+ tumors.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CEACAM5 |
| Reported Applications | in vivo functional assays in vitro functional assays ELISA Western blot Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
-
Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
-
Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
