InVivoSIM anti-human CGRPR (Erenumab biosimilar)
货号 #SIM0103
克隆号:
Erenumab
反应种属:
Human
￥2,527 - ￥87,620
产品详情
This Erenumab biosimilar antibody uses the same variable regions as the therapeutic antibody Erenumab, making it ideal for research use. Erenumab is a fully human IgG2 monoclonal antibody that specifically targets the calcitonin gene-related peptide receptor (CGRPR), a heterodimeric complex composed of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1). The CGRPR is expressed on vascular smooth muscle cells, sensory neurons, and components of the trigeminovascular system, where CGRP signaling drives vasodilation, neurogenic inflammation, and pain transmission associated with migraine pathophysiology. By binding the CGRPR, Erenumab prevents ligand engagement and downstream signaling, thereby inhibiting CGRP-mediated neurovascular activation. This Erenumab biosimilar is well suited for studying CGRPR biology, neurovascular signaling, pain mechanisms, and for benchmarking therapeutic receptor blockade in pre-clinical experimental systems.参数
| 同种型 | Human IgG2, λ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CGRPR |
| Reported Applications | in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
