InVivoSIM anti-human FGF‑23 (Burosumab Biosimilar)
货号 #SIM0079
克隆号:
Burosumab
￥2,527 - ￥87,620
产品详情
This biosimilar antibody uses the same variable regions as the therapeutic antibody Burosumab making it ideal for research use. Burosumab is a fully human IgG1 monoclonal antibody that specifically targets fibroblast growth factor 23 (FGF‑23). It binds circulating FGF‑23, blocking its interaction with the FGFR1–α‑Klotho receptor complex, thereby restoring phosphate homeostasis by enhancing renal phosphate reabsorption and increasing active vitamin D production. FGF‑23 is a hormone secreted by osteocytes and osteoblasts that regulates serum phosphate levels by inhibiting phosphate reabsorption in the kidney and suppressing vitamin D synthesis, ultimately reducing intestinal phosphate absorption. Clinically, Burosumab is approved for the treatment of X‑linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO) in both adults and children. It has demonstrated significant improvements in serum phosphate, bone mineralization, rickets severity, and growth in XLH patients, with sustained efficacy and safety over extended use. This Burosumab biosimilar is well suited for studying phosphate and vitamin D metabolism, endocrine FGF signaling, bone biology, and therapeutic blockade of FGF‑23.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human FGF-23 |
| Reported Applications | in vivo functional assays in vitro functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
