InVivoSIM anti-human IL-31RA (Nemolizumab Biosimilar)
货号 #SIM0078
克隆号:
Nemolizumab
反应种属:
Human
￥2,527 - ￥87,620
产品详情
This non‑therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nemolizumab making it ideal for research use. Nemolizumab is a humanized IgG2 monoclonal antibody that specifically targets the interleukin-31 receptor alpha (IL-31RA). IL‑31RA is primarily expressed on keratinocytes, dorsal root ganglion (DRG) neurons, monocytes, macrophages, and dendritic cells, where it mediates the biological effects of IL‑31, a cytokine known for driving pruritus, inflammation, and epithelial barrier dysfunction. By binding to IL-31RA, it blocks the signaling of interleukin-31 (IL‑31)—a neuroimmune cytokine that drives itch (pruritus), skin inflammation, barrier dysfunction, and fibrosis—thereby interrupting the pathogenic itch–scratch cycle seen in skin disorders like atopic dermatitis (AD) and prurigo nodularis (PN) . Nemolizumab has been shown to provide rapid and sustained relief of pruritus in clinical trials involving AD and PN by modulating neuroimmune pathways, improving skin integrity, and reducing inflammation . This Nemolizumab biosimilar is well suited for studying IL‑31 signaling, neuroimmune interactions in itch, barrier function, and the development of anti-pruritic therapeutics.参数
| 同种型 | Human IgG2, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human IL-31RA |
| Reported Applications | in vivo functional assays in vitro functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
