InVivoSIM anti-human IL1RAP (IL-1R3) (Nadunolimab biosimilar)
货号 #SIM0093
克隆号:
Nadunolimab
反应种属:
Human
￥2,527 - ￥87,620
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nadunolimab, making it ideal for research use. Nadunolimab is a fully human IgG1 monoclonal antibody that targets the interleukin-1 receptor accessory protein (IL1RAP), a co-receptor required for signaling through IL-1 family cytokine receptors including IL-1R1, IL-1R2, IL-33R (ST2), and IL-36 receptors. IL1RAP is overexpressed on a wide range of tumor types, including non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDAC), and several hematologic malignancies, but is expressed at limited levels in normal tissues, making it an attractive therapeutic target. By binding IL1RAP, Nadunolimab blocks downstream IL-1 family signaling, which reduces tumor-promoting inflammation, inhibits NF-κB activation, and diminishes secretion of pro-tumor cytokines. In addition, Nadunolimab’s IgG1 Fc region enables potent antibody-dependent cell-mediated cytotoxicity (ADCC), facilitating direct killing of IL1RAP-expressing tumor cells. Nadunolimab has shown promising clinical activity in solid tumors particularly in combination with chemotherapy by modulating the inflammatory tumor microenvironment and promoting immune-mediated tumor clearance. This Nadunolimab biosimilar is well suited for studying IL-1 family receptor biology, tumor-associated inflammation, IL1RAP-dependent signaling, myeloid-driven immunosuppression, and therapeutic strategies targeting IL1RAP-expressing cancers.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human IL1RAP |
| Reported Applications | in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
