InVivoSIM anti-human IL‑3RA (CD123) (Pivekimab Biosimilar)
货号 #SIM0080
克隆号:
Pivekimab
￥2,527 - ￥87,620
产品详情
This biosimilar antibody uses the same variable regions as the therapeutic antibody Pivekimab, making it ideal for research use. Pivekimab is a humanized IgG1 monoclonal antibody that specifically targets CD123, also known as interleukin‑3 receptor alpha (IL‑3RA). CD123 is highly expressed on malignant hematopoietic cells, including acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN), and plays a critical role in IL‑3–mediated cell survival and proliferation. By binding to CD123, Pivekimab blocks IL‑3 signaling pathways involved in the pathogenesis of myeloid malignancies. While the therapeutic version (pivekimab sunirine) is conjugated to a cytotoxic payload, this Pivekimab biosimilar is unconjugated and intended for research use only. It is well suited for studying IL‑3 signaling, CD123 expression, and receptor blockade in hematologic cancers.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human IL‑3RA |
| Reported Applications | in vivo functional assays in vitro functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
