InVivoSIM anti-human PCSK9 (Bococizumab biosimilar)
货号 #SIM0096
克隆号:
Bococizumab
￥2,527 - ￥87,620
产品详情
This Bococizumab biosimilar antibody uses the same variable regions as the therapeutic antibody Bococizumab, making it ideal for research use. Bococizumab is a humanized IgG2 monoclonal antibody that targets proprotein convertase subtilisin/kexin type 9 (PCSK9), a secreted serine protease that regulates plasma LDL cholesterol by controlling LDL receptor (LDLR) recycling. PCSK9 binds LDLR on hepatocytes and directs the receptor to lysosomal degradation, reducing LDLR surface expression and increasing circulating LDL cholesterol levels. By binding PCSK9 with high affinity, Bococizumab prevents its interaction with LDLR, thereby increasing receptor availability and enhancing LDL clearance. Although therapeutic development of Bococizumab was discontinued due to immunogenicity and variable LDL-lowering responses, it remains a valuable research tool for studying PCSK9–LDLR biology, lipid metabolism, hepatocyte receptor regulation, and mechanisms underlying antibody-mediated PCSK9 inhibition. This Bococizumab biosimilar is well suited for investigating cardiovascular disease pathways, metabolic regulation, and therapeutic strategies targeting the PCSK9–LDLR axis.参数
| 同种型 | Human IgG2, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human PCSK9 |
| Reported Applications | in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
