InVivoSIM anti-human PCSK9 (Evolocumab biosimilar)
货号 #SIM0095
克隆号:
Evolocumab
￥2,527 - ￥87,620
产品详情
This Evolocumab biosimilar antibody uses the same variable regions as the therapeutic antibody Evolocumab, making it ideal for research use. Evolocumab is a fully human IgG2 monoclonal antibody that targets proprotein convertase subtilisin/kexin type 9 (PCSK9), a secreted serine protease that regulates plasma LDL cholesterol levels. PCSK9 binds to LDL receptors (LDLR) on hepatocytes and directs them toward lysosomal degradation, thereby reducing LDLR recycling and increasing circulating LDL cholesterol. By binding PCSK9 with high affinity, Evolocumab prevents its interaction with LDLR, leading to increased receptor availability on hepatocyte surfaces and enhanced clearance of LDL particles from circulation. Clinically, Evolocumab has demonstrated potent LDL-lowering activity in patients with hypercholesterolemia, familial hypercholesterolemia, and cardiovascular disease risk. This Evolocumab biosimilar is well suited for studying PCSK9 biology, lipid metabolism, LDLR regulation, hepatocyte signaling, and the mechanistic basis of therapeutic PCSK9 inhibition.参数
| 同种型 | Human IgG2, λ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human PCSK9 |
| Reported Applications | in vivo functional assays in vitro functional assays ELISA Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
