InVivoSIM anti-human sclerostin (SOST) (Romosozumab Biosimilar)
货号 #SIM0068
克隆号:
Romosozumab
反应种属:
Human
￥2,527 - ￥87,620
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Romosozumab, making it ideal for research use. Romosozumab is a humanized IgG2κ monoclonal antibody that targets sclerostin (SOST), a secreted glycoprotein produced by osteocytes. Sclerostin negatively regulates bone formation by binding LRP4/5/6 and inhibiting Wnt/β‑catenin signaling—a key pathway for osteoblast activity. By neutralizing sclerostin, Romosozumab promotes bone formation while simultaneously suppressing bone resorption. This Romosozumab biosimilar is intended for non-therapeutic research use and can support studies on osteoanabolic mechanisms, Wnt signaling, and sclerostin function in bone biology.参数
| 同种型 | Human IgG2, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 6.0T Dilution Buffer |
| 免疫原 | Human SOST |
| Reported Applications | In vitro and ex vivo assays of sclerostin neutralization ELISA Western blot Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 6.0T Dilution Buffer
