InVivoSIM anti-respiratory syncytial virus (RSV) F protein (Nirsevimab Biosimilar)
货号 #SIM0088
克隆号:
Nirsevimab
￥2,527 - ￥87,620
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nirsevimab, making it ideal for research use. Nirsevimab is a human IgG1 monoclonal antibody that targets the fusion (F) glycoprotein of respiratory syncytial virus (RSV), a highly contagious virus that causes serious respiratory infections, particularly in infants and older adults. The RSV F protein plays a critical role in viral entry by mediating the fusion of viral and host cell membranes, making it a key target for neutralization. Nirsevimab binds to a highly conserved epitope on the prefusion conformation of the RSV F protein, thereby preventing the conformational changes required for membrane fusion and subsequent infection. Unlike palivizumab, which binds both pre- and postfusion forms, Nirsevimab is specific to the prefusion form, enabling higher potency and prolonged protection. This Nirsevimab biosimilar is ideal for studying RSV entry mechanisms, neutralizing antibody responses, and RSV vaccine or therapeutic development.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | RSV F protein |
| Reported Applications | In vivo functional assays in vitro functional assays Flow cytometry ELISA |
| 形式 | pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
