InVivoSIM GIPR/GLP‑1R Dual Agonist (Tirzepatide Biosimilar)
货号 #SIM0083
克隆号:
N/A
￥2,798 - ￥17,633
产品详情
This research-grade Tirzepatide biosimilar is a long-acting dual agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP‑1R). Tirzepatide is a synthetic 39-amino acid peptide designed to mimic the native GIP hormone but chemically modified with a C20 fatty diacid moiety to enhance half-life and stability. By selectively activating both GIP and GLP‑1 receptors, key incretin receptors expressed on pancreatic beta cells and hypothalamic neurons, tirzepatide stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite, resulting in lower blood glucose and body weight. In experimental research, tirzepatide has demonstrated potent glucose-lowering activity, enhanced insulin sensitivity, and appetite regulation. It has been used in models of type 2 diabetes (T2D) and is also being studied for its effects on cardiovascular health, chronic kidney disease (CKD), Alzheimer’s disease, metabolic dysfunction-associated nonalcoholic steatohepatitis disease (MASLD), and obstructive sleep apnea (OSA). This tirzepatide biosimilar is ideal for investigating GIPR/GLP‑1R signaling, metabolic hormone synergy, and incretin biology in disease-relevant models.参数
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
|---|---|
| Reported Applications | in vitro functional assays in vivo functional assays ex vivo functional assays |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 分子量 | 4.81 |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
