InVivoSIM GLP-1 Receptor Agonist (Dulaglutide Biosimilar)
货号 #SIM0077
克隆号:
N/A
￥2,798 - ￥17,633
产品详情
This research-grade Dulaglutide biosimilar is a recombinant glucagon-like peptide-1 (GLP-1) analog useful for studies on metabolic disorders, especially type 2 diabetes mellitus (T2DM) and related conditions. Dulaglutide consists of amino acids 7–37 of GLP-1 covalently linked to the Fc fragment of human IgG4, wherein the Fc fragment protects the GLP-1 moiety from enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), thereby extending its stability. As an incretin mimetic, dulaglutide acts as an agonist of the GLP-1 receptor (GLP-1R), a G protein–coupled receptor that plays a central role in regulating glucose homeostasis, insulin secretion, gastric emptying, and satiety. Binding of GLP-1 or its analogs to GLP-1R activates adenylyl cyclase, increasing intracellular cAMP levels and triggering insulin release in a glucose-dependent manner. Through this mechanism, dulaglutide enhances insulin secretion when glucose levels are elevated, reduces glucagon secretion, and delays gastric emptying, thereby lowering postprandial glucose levels. Extensive in vitro and in vivo studies have shown dulaglutide to stimulate glucose-dependent insulin secretion, suppress obesity, improve cardiovascular risk factors, and offer protection against T2DM-associated conditions including sarcopenia, neuroinflammation, and kidney disease. Chronic treatment studies in animal models, including rats, transgenic mice, and monkeys, have been reported, with many mouse studies documenting the use of dulaglutide at 0.6 mg/kg for multi-week experiments.参数
| 同种型 | Human IgG4, κ |
|---|---|
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| Reported Applications | in vitro functional assays in vivo functional assays |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | ≤1EU/mg (≤0.001EU/μg) Determined by LAL assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | ≥95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 59.7 |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
