InVivoMAb anti-human VISTA
货号 #BE0436
克隆号:
GG8
反应种属:
Human
￥1,792 - ￥46,736
产品详情
The GG8 monoclonal antibody reacts with human VISTA (V-type immunoglobulin domain-containing suppressor of T cell activation), which is a negative checkpoint regulator (NCR) from the B7 family. Several in vitro and in vivo studies have demonstrated that the VISTA protein acts as a ligand as well as a receptor. VISTA is mainly expressed by myeloid cells and T cells, and in the CNS, VISTA is also expressed by microglial and endothelial cells. Unlike other NCR proteins, VISTA is expressed on naïve T cells, wherein its expression is negatively regulated by T cell activation. Besides its role in regulation of T cell quiescence (i.e., the suppression of T cells), VISTA is involved in efferocytosis, cytokine production (IL-10, IFN-gamma, and TNF-alpha), and chemotaxis in myeloid cells.参数
| 同种型 | Mouse IgG1, κ |
|---|---|
| 推荐的同型对照 | InVivoMAb mouse IgG1 isotype control, unknown specificity |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Not available or unknown |
| Reported Applications | Immunohistochemistry-paraffin Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein G |
| 分子量 | 150 kDa |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
InVivoMAb mouse IgG1 isotype control, unknown specificity
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
