InVivoSIM anti-human IL-23 (p19) (Guselkumab Biosimilar)

货号 #SIM0025
克隆号:
Guselkumab
反应种属:
Human

¥2,336 - ¥80,624

选择参数
  • 100 mg - ¥80,624
  • 50 mg - ¥45,296
  • 25 mg - ¥31,520
  • 5 mg - ¥9,024
  • 1 mg - ¥2,336
  • 定制包装(请询价)

产品详情

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Guselkumab making it ideal for research use. This Guselkumab biosimilar reacts with the p19 subunit of human IL-23. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections. Guselkumab targets the IL-23 p19 subunit preventing it from binding to cell receptors that would otherwise be activated by its presence. Guselkumab is used to treat moderate to severe plaque psoriasis, and psoriatic arthritis.

参数

同种型 Human IgG1, λ
推荐的同型对照 RecombiMAb human IgG1 isotype control, anti-respiratory syncytial virus
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Human IL-23 p19
Reported Applications IL-23p19 neutralization Functional assays ELISA Western blot
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <1EU/mg (<0.001EU/μg) Determined by LAL gel clotting assay
聚合 <5% Determined by SEC
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from tissue culture supernatant in an animal free facility
提纯 Protein A
分子量 150 kDa
小鼠病原体试验 Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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