InVivoMAb anti-mouse/rat/rabbit TNFα

货号 #BE0244
克隆号:
TN3-19.12
反应种属:
Mouse

¥1,712 - ¥44,512

选择参数
  • 100 mg - ¥44,512
  • 50 mg - ¥31,456
  • 25 mg - ¥20,896
  • 5 mg - ¥6,240
  • 1 mg - ¥1,712
  • 定制包装(请询价)

产品详情

The TN3-19.12 monoclonal antibody reacts with mouse, rat, and rabbit TNFα (tumor necrosis factor-alpha) a multifunctional proinflammatory cytokine. TNFα exists as a soluble 17 kDa monomer, which forms homotrimers in circulation or as a 26 kDa membrane-bound form. TNFα belongs to the TNF superfamily of cytokines and signals through its two receptors, TNFR1 and TNFR2 which can be activated by both the soluble trimeric and membrane-bound and forms of TNFα. TNFα is primarily produced by macrophages in response to foreign antigens such as bacteria (lipopolysaccharides), viruses, and parasites as well as mitogens and other cytokines but can also be expressed by monocytes, neutrophils, NK cells, CD4 T cells and some specialized dendritic cells. TNFα is known to play key roles in a wide spectrum of biological processes including immunoregulation, cell proliferation, differentiation, apoptosis, antitumor activity, inflammation, anorexia, cachexia, septic shock, hematopoiesis, and viral replication. TNFα dysregulation has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Mouse and human TNFα share 79% amino acid sequence identity however, mouse TNFα is glycosylated while human TNFα is not. TNFα knockout animals display defects in response to bacterial infection, characterized by defects in forming organized follicular dendritic cell networks and germinal centers with a lack of primary B cell follicles. The TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-α.

参数

同种型 Armenian Hamster IgG, κ
推荐的同型对照 InVivoMAb polyclonal Armenian hamster IgG
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Recombinant mouse TNFα
Reported Applications in vivo TNFα neutralization Flow cytometry
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtered
生产 Purified from tissue culture supernatant in an animal free facility
提纯 Protein G
RRID AB_2687725
分子量 150 kDa
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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