InVivoMAb anti-mouse 4-1BB (CD137)

货号 #BE0169
克隆号:
LOB12.3
反应种属:
Mouse

¥1,792 - ¥46,736

选择参数
  • 100 mg - ¥46,736
  • 50 mg - ¥33,024
  • 25 mg - ¥21,936
  • 5 mg - ¥6,560
  • 1 mg - ¥1,792
  • 定制包装(请询价)

产品详情

The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growth in vivo when administered in combination with immune checkpoint inhibitors.

参数

同种型 Rat IgG1, κ
推荐的同型对照 InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
推荐稀释缓冲液 InVivoPure pH 8.0 Dilution Buffer
免疫原 Mouse CD137 human Fc fusion protein
Reported Applications in vivo activation of 4-1BB
形式 PBS, pH 8.0 Contains no stabilizers or preservatives
内毒素 <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from cell culture supernatant in an animal-free facility
提纯 Protein G
RRID AB_10949016
分子量 150 kDa
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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