InVivoMAb anti-mouse VISTA
货号 #BE0423
克隆号:
8G8
反应种属:
Mouse
¥1,792 - ¥46,736
产品详情
The 8G8 monoclonal antibody reacts with mouse V-domain Ig suppressor of T cell activation (VISTA) also known as PD-1H and B7-H5. VISTA is a 309 aa type I transmembrane glycoprotein and a member of the Ig superfamily. VISTA is expressed on naïve and activated T cells, NK cells, macrophages, dendritic cells, and neutrophils. VISTA functions as a negative immune-checkpoint protein that suppresses T cell cytokine production and proliferation. VISTA is overexpressed by tumor-infiltrating lymphocytes, such as myeloid cells and regulatory T cells. The 8G8 antibody is an agonistic antibody and has demonstrated immunosuppressive properties in multiple murine models of inflammation and autoimmunity including lupus, hepatitis, arthritis, and psoriasis.参数
同种型 | Armenian hamster IgG |
---|---|
推荐的同型对照 | InVivoMAb polyclonal Armenian hamster IgG |
推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
免疫原 | Not available or unknown |
Reported Applications | in vivo stimulation of VISTA signaling |
形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
内毒素 | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
纯化 | >95% Determined by SDS-PAGE |
无菌性 | 0.2 μM filtration |
生产 | Purified from cell culture supernatant in an animal-free facility |
提纯 | Protein G |
分子量 | 150 kDa |
保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |