InVivoMAb anti-mouse VISTA

货号 #BE0423
克隆号:
8G8
反应种属:
Mouse

¥1,792 - ¥46,736

选择参数
  • 100 mg - ¥46,736
  • 50 mg - ¥33,024
  • 25 mg - ¥21,936
  • 5 mg - ¥6,560
  • 1 mg - ¥1,792
  • 定制包装(请询价)

产品详情

The 8G8 monoclonal antibody reacts with mouse V-domain Ig suppressor of T cell activation (VISTA) also known as PD-1H and B7-H5. VISTA is a 309 aa type I transmembrane glycoprotein and a member of the Ig superfamily. VISTA is expressed on naïve and activated T cells, NK cells, macrophages, dendritic cells, and neutrophils. VISTA functions as a negative immune-checkpoint protein that suppresses T cell cytokine production and proliferation. VISTA is overexpressed by tumor-infiltrating lymphocytes, such as myeloid cells and regulatory T cells. The 8G8 antibody is an agonistic antibody and has demonstrated immunosuppressive properties in multiple murine models of inflammation and autoimmunity including lupus, hepatitis, arthritis, and psoriasis.

参数

同种型 Armenian hamster IgG
推荐的同型对照 InVivoMAb polyclonal Armenian hamster IgG
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Not available or unknown
Reported Applications in vivo stimulation of VISTA signaling
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from cell culture supernatant in an animal-free facility
提纯 Protein G
分子量 150 kDa
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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