RecombiMAb anti-mouse CD38
货号 #CP052
克隆号:
NIMR5-CP052
反应种属:
Mouse
￥5,632 - ￥76,176
产品详情
The NIMR5-CP052 monoclonal antibody is a chimeric version of the original NIMR5 antibody. The variable domain sequences are identical to the original NIMR5 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. The NIMR5-CP052 monoclonal antibody reacts with mouse CD38 a 42 kDa type II transmembrane glycoprotein. CD38 is expressed on immature and mature resting and activated B cells as well as NK cells and a subset of T cells. CD38 expression is down-regulated on mouse germinal center B cells and plasma cells. CD38 is a multifunctional protein involved in NAD homeostasis and in the generation of the second messengers ADPR and cyclic ADPR which are involved in intracellular calcium signaling. Antibodies against CD38 have been shown to be highly efficacious in the treatment of multiple myeloma. The original NIMR5 antibody is reported as an agonistic antibody and has been shown to induce B cell proliferation, protect B cells from apoptosis, and slow disease progression in tumor-bearing mice.参数
| 同种型 | Mouse IgG2a, κ |
|---|---|
| 推荐的同型对照 | InVivoPlus mouse IgG2a isotype control, unknown specificity |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | BCL1 plasma membrane glycoproteins |
| Reported Applications | in vivo CD38 stimulation* in vitro CD38 stimulation* in vitro B cell activation* Immunofluorescence* ELISA* Flow cytometry* *Reported for the original rat IgG2a NIMR5 antibody |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <1EU/mg (<0.001EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from HEK293 cell supernatant in an animal-free facility |
| 提纯 | Protein G |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Isotype Control(s)
InVivoPlus mouse IgG2a isotype control, unknown specificity
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
