InVivoMAb anti-human EGFR

货号 #BE0278
克隆号:
225 (HB-8508)
反应种属:
Human

¥1,712 - ¥44,512

选择参数
  • 100 mg - ¥44,512
  • 50 mg - ¥31,456
  • 25 mg - ¥20,896
  • 5 mg - ¥6,240
  • 1 mg - ¥1,712
  • 定制包装(请询价)

产品详情

The 225 monoclonal antibody reacts with an epitope on the extracellular domain of human EGFR belongs to the ErbB family of receptors. EGFR signaling is activated upon binding one of its ligands including epidermal growth factor (EGF), transforming growth factor α (TGF α), Amphiregulin, and heparin binding EGF (HB-EGF). Upon activation, EGFR transitions from an inactive monomeric form to an active homodimer. This initiates several downstream signal transduction cascades including the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. EGFR overexpression or constitutive activation are associated with many cancers. For this reason, anti-EGFR monoclonal antibody mediated immunotherapies are currently being explored as cancer treatments. The 225 antibody has been reported to neutralize EGFR signaling.

参数

同种型 Mouse IgG1
推荐的同型对照 InVivoMAb mouse IgG1 isotype control, unknown specificity
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Purified EGFR from A431 cells
Reported Applications in vitro EGFR blockade in vivo EGFR blockade in xenografts Western blot Functional assays
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from tissue culture supernatant in an animal free facility
提纯 Protein G
RRID AB_2687801
分子量 150 kDa
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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