InVivoMAb anti-human EGFR

货号 #BE0375
克隆号:
425
反应种属:
Human

¥1,712 - ¥44,512

选择参数
  • 100 mg - ¥44,512
  • 50 mg - ¥31,456
  • 25 mg - ¥20,896
  • 5 mg - ¥6,240
  • 1 mg - ¥1,712
  • 定制包装(请询价)

产品详情

The 425 monoclonal antibody reacts with an epitope on the extracellular domain of human EGFR (epidermal growth factor receptor) also known as ErbB-1. EGFR is a 170 kDa cell-surface receptor and belongs to the ErbB family of receptors. EGFR signaling is activated upon binding one of its ligands including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin, and heparin binding-EGF (HB-EGF). Upon activation, EGFR transitions from an inactive monomeric form to an active homodimer. This initiates several downstream signal transduction cascades including the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. EGFR overexpression or constitutive activation are associated with many cancers. For this reason, anti-EGFR monoclonal antibody mediated immunotherapies are currently being explored as cancer treatments. The 425 antibody does not induce tyrosine kinase activity but inhibits the binding of EGF and transforming growth factor α (TGFα) to EGFR, which results in tumor growth inhibition in vitro and in vivo.

参数

同种型 Mouse IgG2a, κ
推荐的同型对照 InVivoMAb mouse IgG2a isotype control, unknown specificity
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Human A431 carcinoma cells
Reported Applications in vivo EGFR blockade in xenografts in vitro EGFR blockade Immunoprecipitation
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
提纯 Protein A
RRID AB_2927512
分子量 150 kDa
保存 The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.
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