InVivoMAb anti-mouse IL-23 (p19)

货号 #BE0313
克隆号:
G23-8
反应种属:
Mouse

¥10,784 - ¥44,512

选择参数
  • 100 mg - ¥44,512
  • 50 mg - ¥31,456
  • 25 mg - ¥20,896
  • 10 mg - ¥10,784
  • 定制包装(请询价)

产品详情

The G23-8 monoclonal antibody reacts with the p19 subunit of mouse IL-23. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, mouse IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Mouse IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections. The G23-8 antibody can specifically neutralize IL-23 bioactivity with no effect on IL-12 p70 bioactivity.

参数

同种型 Rat IgG1, κ
推荐的同型对照 InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Insect cell-expressed, recombinant mouse IL-23 heterodimer
Reported Applications in vivo IL-23p19 neutralization Western blot
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from tissue culture supernatant in an animal free facility
提纯 Protein G
RRID AB_2754551
分子量 150 kDa
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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