InVivoSIM anti-human 4-1BB (Urelumab Biosimilar)

货号 #SIM0058
克隆号:
Urelumab
反应种属:
Human

¥2,448 - ¥84,656

选择参数
  • 100 mg - ¥84,656
  • 50 mg - ¥47,568
  • 25 mg - ¥33,088
  • 5 mg - ¥9,472
  • 1 mg - ¥2,448
  • 定制包装(请询价)

产品详情

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody, Urelumab, making it ideal for research use. Urelumab reacts with 4-1BB, also known as CD137 antigen, TNF receptor superfamily member 9, or induced by lymphocyte activation. Urelumab has been engineered as a humanized IgG4 monoclonal antibody to reduce its non-specific binding to Fc receptors. Urelumab has a hinge mutation, S228P, which prevents IgG4 Fab exchange, thereby improving stability. CD137 is a type 1 membrane glycoprotein receptor that belongs to the tumor necrosis factor (TNF) superfamily, and it is expressed in lymphoid tissues. Upon activation, CD137 is expressed on the surface of several immune cells, including T cells (CD4+ and CD8+), NKT cells, regulatory T cells, eosinophils, and dendritic cells. Notably, CD137 is not expressed on the surface of resting T and B cells, as well as activated B lymphocytes, rendering it an advantageous biomarker for immunological activation. CD137L is an established ligand of CD137, and the CD137-CD137L signaling pathway augments and prolongs T-cell reactivity to alloantigens. Urelumab is an agonistic antibody that replicates cross-linking by the endogenous ligand (i.e., CD137-CD137L), and this antibody triggers a robust costimulatory signal in antigen-primed T cells, enhances the ADCC of NK cells, and boosts the T cell-mediated antitumor immunity.

参数

同种型 Human IgG1, κ
推荐的同型对照 RecombiMAb human IgG4 (S228P) isotype control, anti-hen egg lysozyme
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Human 4-1BB (CD137)
Reported Applications in vivo 4-1BB stimulation in vitro 4-1BB stimulation Functional assays Immunoprecipitation Flow cytometry ELISA
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay
聚合 <5% Determined by SEC
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from cell culture supernatant in an animal-free facility
提纯 Protein A
分子量 150 kDa
小鼠病原体试验 Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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