InVivoSIM anti-human AXL (Tilvestamab Biosimilar)
货号 #SIM0065
克隆号:
Tilvestamab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody utilizes the same variable regions as the therapeutic antibody Tilvestamab making it ideal for research use. Tilvestamab targets the AXL receptor tyrosine kinase, a member of the TAM (Tyro3, AXL, Mer) family. AXL is overexpressed in various malignancies, including renal cell carcinoma, non-small cell lung cancer, pancreatic cancer, and triple-negative breast cancer, and is associated with tumor progression, metastasis, and resistance to therapy. By binding to the extracellular domain of AXL, Tilvestamab inhibits the interaction with its ligand Gas6, thereby blocking downstream signaling pathways such as PI3K/AKT and MAPK/ERK. This blockade results in the suppression of tumor cell proliferation, migration, and survival. Preclinical studies have demonstrated that Tilvestamab effectively reduces AXL activation and downstream signaling, leading to decreased tumor growth in vivo. This biosimilar antibody serves as a valuable tool for studying AXL-mediated signaling, tumor biology, and the development of AXL-targeted therapies.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human AXL |
| Reported Applications | Functional assays Flow cytometry Western blot ELISA in vivo studies using xenograft models |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
