InVivoSIM anti-human BCMA (Belantamab Biosimilar)

货号 #SIM0056
克隆号:
Belantamab
反应种属:
Human

¥2,448 - ¥84,656

选择参数
  • 100 mg - ¥84,656
  • 50 mg - ¥47,568
  • 25 mg - ¥33,088
  • 5 mg - ¥9,472
  • 1 mg - ¥2,448
  • 定制包装(请询价)

产品详情

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody, Belantamab, making it ideal for research use. Belantamab is a humanized IgG1 monoclonal antibody that reacts with B-cell maturation antigen (BCMA), also known as CD269 or tumor necrosis factor receptor superfamily member 17 (TNFRSF17). BCMA is a single-pass type III membrane glycoprotein, and it is selectively expressed by mature or differentiated plasma B-cells in normal lymphoid tissues (e.g., bone marrow, spleen, lymph nodes, and tonsils). BCMA is not expressed on naive B cells, T cells, monocytes/macrophages, neutrophils, and other normal tissues. BCMA is expressed uniformly and in high abundance in multiple myeloma tissues, and its low-to-moderate levels of expression are reported in several other hematologic malignancies also (e.g., chronic lymphocytic leukemia, acute B-lymphoblastic leukemia, and non-Hodgkin/Hodgkin lymphomas). BCMA acts as a receptor for two distinct agonist ligands: B cell-activating factor [BAFF (also known as TNFSF13B or BLyS)] and a proliferation-inducing ligand (APRIL, also called TNFSF13). In comparison to BAFF/Blys, BCMA binds APRIL/TNFSF13 with higher affinity. BCMA plays a critical role in promoting B-cell survival and the regulation of humoral immunity. BCMA is also involved in the activation of NF-kappa-B and JNK-3 signaling pathways. In multiple myeloma, BCMA expression is directly related to the growth/proliferation of cancer cells, and serum levels of soluble BCMA (sBCMA) are suggested as a potential biomarker in multiple myeloma. In several experimental studies, an antibody-drug conjugate (ADC) consisting of belantamab conjugated to mafodotin has been shown to induce antibody-dependent cellular cytotoxicity (ADCC) and apoptosis in cancer cells.

参数

同种型 Human IgG1, κ
推荐的同型对照 RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Human BCMA (CD269)
Reported Applications in vivo functional assays in vitro functional assays Flow cytometry Immunoprecipitation Western blot ELISA
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay
聚合 <5% Determined by SEC
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from cell culture supernatant in an animal-free facility
提纯 Protein A
分子量 150 kDa
小鼠病原体试验 Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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