InVivoSIM anti-human CD79b (Polatuzumab Biosimilar)
货号 #SIM0060
克隆号:
Polatuzumab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Polatuzumab, making it ideal for research use. Polatuzumab is a humanized IgG1 monoclonal antibody that targets CD79b, a critical component of the B cell receptor (BCR) complex. CD79b, also known as Igβ, forms a heterodimer with CD79a (Igα) and is essential for signal transduction following antigen engagement of surface immunoglobulin. The CD79a/CD79b complex initiates downstream signaling cascades that regulate B cell development, activation, proliferation, and survival. CD79b is expressed throughout most stages of B cell maturation but is absent from plasma cells and non-B lineage cells. Importantly, CD79b is retained on the surface of many malignant B cells, including those in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, making it an attractive therapeutic and diagnostic target. Polatuzumab serves as the antibody backbone for the FDA-approved antibody-drug conjugate Polatuzumab vedotin, which delivers a cytotoxic MMAE payload to CD79b+ cells. In contrast, this unconjugated biosimilar form lacks any drug conjugation, allowing researchers to study CD79b-specific antibody binding, internalization, and function without the confounding effects of cytotoxicity. This Polatuzumab biosimilar antibody retains the antigen-binding domains of the therapeutic but is produced for non-clinical research use. It is suitable for a range of applications, including flow cytometry, B cell targeting studies, preclinical modeling, and ADC development.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CD79b |
| Reported Applications | Functional assays Flow cytometry Immunoprecipitation ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
