InVivoSIM anti-human CEACAM6 (Tinurilimab Biosimilar)
货号 #SIM0063
克隆号:
Tinurilimab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Tinurilimab making it ideal for research use. Tinurilimab is a humanized IgG2 monoclonal antibody that targets CEACAM6 (CD66c), a member of the carcinoembryonic antigen-related cell adhesion molecule family. CEACAM6 is overexpressed in various epithelial cancers, including non-small cell lung cancer (NSCLC), pancreatic, gastric, colorectal, and breast cancers, and is associated with tumor progression and poor prognosis. CEACAM6 functions as an immune checkpoint regulator, suppressing the activity of effector T-cells against tumors. By binding to CEACAM6, Tinurilimab may enhance anti-tumor immune responses by relieving this suppression. Additionally, CEACAM6 contributes to epithelial-mesenchymal transition (EMT), invasion, and metastasis, making it a valuable target for cancer research. This biosimilar antibody is well-suited for studies involving CEACAM6-mediated signaling, tumor immunology, and the development of CEACAM6-targeted therapies.参数
| 同种型 | Human IgG2, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CEACAM6 |
| Reported Applications | Functional assays ELISA Immunohistochemistry Western blot Flow cytometry |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
