InVivoSIM anti-human CEACAM6 (Tinurilimab Biosimilar)

货号 #SIM0063
克隆号:
Tinurilimab
反应种属:
Human

¥2,448 - ¥84,656

选择参数
  • 100 mg - ¥84,656
  • 50 mg - ¥47,568
  • 25 mg - ¥33,088
  • 5 mg - ¥9,472
  • 1 mg - ¥2,448
  • 定制包装(请询价)

产品详情

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Tinurilimab making it ideal for research use. Tinurilimab is a humanized IgG2 monoclonal antibody that targets CEACAM6 (CD66c), a member of the carcinoembryonic antigen-related cell adhesion molecule family. CEACAM6 is overexpressed in various epithelial cancers, including non-small cell lung cancer (NSCLC), pancreatic, gastric, colorectal, and breast cancers, and is associated with tumor progression and poor prognosis. CEACAM6 functions as an immune checkpoint regulator, suppressing the activity of effector T-cells against tumors. By binding to CEACAM6, Tinurilimab may enhance anti-tumor immune responses by relieving this suppression. Additionally, CEACAM6 contributes to epithelial-mesenchymal transition (EMT), invasion, and metastasis, making it a valuable target for cancer research. This biosimilar antibody is well-suited for studies involving CEACAM6-mediated signaling, tumor immunology, and the development of CEACAM6-targeted therapies.

参数

同种型 Human IgG2, κ
推荐的同型对照 RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
推荐稀释缓冲液 InVivoPure pH 7.0 Dilution Buffer
免疫原 Human CEACAM6
Reported Applications Functional assays ELISA Immunohistochemistry Western blot Flow cytometry
形式 PBS, pH 7.0 Contains no stabilizers or preservatives
内毒素 <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay
聚合 <5% Determined by SEC
纯化 >95% Determined by SDS-PAGE
无菌性 0.2 μM filtration
生产 Purified from cell culture supernatant in an animal-free facility
提纯 Protein A
分子量 150 kDa
小鼠病原体试验 Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative
保存 The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
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