InVivoSIM anti-human FcRn (FCGRT) (Nipocalimab Biosimilar)
货号 #SIM0062
克隆号:
Nipocalimab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nipocalimab, making it ideal for research use. Nipocalimab is a fully human IgG1 monoclonal antibody that targets the neonatal Fc receptor (FcRn), a key regulator of IgG homeostasis and recycling. FcRn binds to IgG antibodies at acidic pH in endosomes and protects them from lysosomal degradation by recycling them back to the cell surface, where they are released at neutral pH. This process extends the half-life of circulating IgG antibodies. FcRn is expressed in a variety of cell types, including endothelial cells, epithelial cells (such as those in the lung, intestine, and placenta), monocytes, macrophages, dendritic cells, and neutrophils. Its widespread expression supports systemic IgG regulation, tissue-level antibody transport, and immune homeostasis. By binding to FcRn, Nipocalimab competitively inhibits endogenous IgG from interacting with FcRn, thereby accelerating IgG catabolism and reducing total IgG levels in circulation. This mechanism has therapeutic implications for IgG-mediated autoimmune diseases, where pathogenic autoantibodies contribute to disease pathology. This Nipocalimab biosimilar antibody is intended for non-therapeutic research use only and is an excellent tool for studying FcRn biology, IgG clearance, antibody recycling, and the development of FcRn-targeting therapeutics.参数
| 同种型 | Human IgG1, λ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 (N297A) isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human FcRn |
| Reported Applications | Functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 (N297A) isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
