InVivoSIM anti-human FGFR2b (CD332) (Bemarituzumab Biosimilar)
货号 #SIM0052
克隆号:
Bemarituzumab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody, Bemarituzumab, making it ideal for research use. Bemarituzumab is a humanized IgG1κ anti-human FGFR2b (CD332) antibody, which reacts with the fibroblast growth factor receptor 2 IIIb isoform (FGFR2b) of FGFR2. FGFR2 is a member of a family of four FGF receptors that interact with over 20 different fibroblast growth factors (FGFs), each of which shows relatively unique and restricted expression to specific tissues, cell types, and/or developmental stages. FGF7, FGF10, and FGF22 are the main ligands of FGFR2b. FGFR2b is expressed in epithelial tissues such as the stomach and skin and is often found overexpressed in gastric cancers. FGF-FGFR2 signaling is involved in many cancers, such as gastric, breast, ovarian, endometrial, lung, and bile duct cancers. Bemarituzumab has recently been introduced for the therapeutic blockade of FGFR2b signaling. In combination with anti-cancer experimental therapeutics, bemarituzumab is documented to exhibit substantial synergism in vivo with immune checkpoint blockage via anti-PD-1 or chemotherapy. NOTE: The CHOK1BN-Fut8KO cell line was not used to express this bemarituzumab antibody (SIM0052), so it is NOT afucosylated.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 (K214R/L234F/L235E/P331S) isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human FGFR2b |
| Reported Applications | in vivo functional assays in vitro functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 (K214R/L234F/L235E/P331S) isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
