InVivoSIM anti-human GDF15 (Ponsegromab Biosimilar)
货号 #SIM0059
克隆号:
Ponsegromab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody, Ponsegromab, making it ideal for research use. Ponsegromab targets GDF15, also known as growth differentiation factor 15, MIC-1, or NAG-1, a distant member of the transforming growth factor-beta (TGF-β) superfamily. GDF15 is a secreted cytokine that plays a critical role in energy homeostasis, appetite regulation, and the stress response. It is expressed at low levels under physiological conditions but is strongly upregulated in response to cellular stress, tissue injury, inflammation, and malignancy. Ponsegromab is a human IgG1 monoclonal antibody that binds with high specificity to circulating GDF15, thereby preventing its interaction with its cognate receptor, GFRAL, which is predominantly expressed in the area postrema and nucleus tractus solitarius of the brainstem. GDF15-GFRAL signaling has been implicated in the induction of anorexia and weight loss, particularly in chronic diseases such as cancer and heart failure. By blocking this pathway, Ponsegromab has been shown to reverse cachexia-associated anorexia in preclinical models. This antibody is useful for investigating the biological function of the GDF15-GFRAL axis, modeling therapeutic blockade of GDF15, and exploring the regulation of appetite and body weight in disease contexts. It may also be used to probe the immunometabolic consequences of stress-related cytokine signaling.参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 (K214R/L234F/L235E/P331S) isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human GDF15 |
| Reported Applications | Functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Isotype Control(s)
RecombiMAb human IgG1 (K214R/L234F/L235E/P331S) isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
