InVivoSIM anti-human GPNMB (Glembatumumab Biosimilar)
货号 #SIM0066
克隆号:
Glembatumumab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody utilizes the same variable regions as the therapeutic antibody Glembatumumab, making it ideal for research use. Glembatumumab is a fully human IgG2 monoclonal antibody that targets glycoprotein non-metastatic melanoma protein B (GPNMB), a transmembrane glycoprotein overexpressed in various cancers, including triple-negative breast cancer (TNBC), melanoma, glioblastoma, and osteosarcoma. GPNMB is associated with tumor progression, metastasis, and poor prognosis. In therapeutic applications, Glembatumumab is conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) to form the antibody-drug conjugate (ADC) Glembatumumab vedotin. This ADC binds to GPNMB-expressing tumor cells, is internalized, and releases MMAE intracellularly, leading to cell death. However, this biosimilar is unconjugated and formulated for non-therapeutic research use only, making it an excellent tool for studying GPNMB biology, tumor immunology, and the development of GPNMB-targeted therapies.参数
| 同种型 | Human IgG2, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human GPNMB |
| Reported Applications | Functional assays Flow cytometry ELISA Immunohistochemistry Western blot |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
