InVivoSIM anti-human IL-33 (Etokimab Biosimilar)
货号 #SIM0053
克隆号:
Etokimab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody, Etokimab, making it ideal for research use. Etokimab is a humanized IgG1 monoclonal antibody that reacts with interleukin-33 (IL-33) of human and cynomolgus monkey species. IL-33 is a member of the IL-1 family of cytokines, and it is constitutively expressed by epithelial cells, endothelial cells, and fibroblastic stromal cells. IL-33 is an alarmin cytokine which is released when a cell or tissue is damaged. IL-33 plays an important role in tissue homeostasis/repair, type 2 immunity, viral infection, allergic and non-allergic inflammation, and cancer. The binding of secreted IL-33 to its receptor ST2, also called the IL-1 receptor accessory protein (IL-1RAP) heterodimer, triggers MyD88-dependent NF-κB or AP-1 signaling pathways, thereby upregulating inflammatory cytokines crucial to the pathogenesis of both allergic and non-allergic inflammatory disorders. IL-33 targets Th1 cells, Th2 cells, basophils, eosinophils, macrophages, DCs, neutrophils, CD8+ T cells, NK cells, and iNKT cells. The etokimab antibody (formerly known as ANB020) has been shown to inhibit the release of IFN-γ by IL-33/IL-12 in in vitro preclinical experiments. Etokimab has been used to neutralize IL-33 in various diseases, including atopic dermatitis (AD), eosinophilic asthma, and chronic rhinosinusitis with nasal polyps (CRSwNP), as well as allergic inflammation in various tissues (such as skin and nasopharyngeal/pulmonary tissues).参数
| 同种型 | Human IgG1, κ |
|---|---|
| 推荐的同型对照 | RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme |
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human IL-33 |
| Reported Applications | in vivo functional assays in vitro functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
推荐产品
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
